Are there clinical phenotypes of homozygous sickle cell disease?
نویسندگان
چکیده
منابع مشابه
Recurrent infections in homozygous sickle cell disease.
The characteristics of 214 episodes of invasive bacterial infection among 176 patients with homozygous sickle cell (SS) disease were examined. Streptococcus pneumoniae occurred in 81 episodes, Salmonella spp in 70, Haemophilus influenzae type b in 30, Escherichia coli in 24, and Klebsiella spp in nine. The cumulative incidence showed that S pneumoniae and H influenzae occurred predominantly bef...
متن کاملAntiphospholipid antibodies in homozygous sickle cell disease.
Serum samples from 108 unselected Jamaican patients with homozygous sickle cell disease and 116 control subjects with normal haemoglobin were screened for the presence of antiphospholipid antibodies. Slightly increased levels of IgG antiphospholipid antibodies were found in nine patients with sickle cell disease and in none of the control subjects. Serial control samples confirmed the increased...
متن کاملErythrocyte aggregation in homozygous sickle cell disease.
Amparo Vayáa,∗, Susana Colladoa, Rafael Alisb,c and Maria-Angeles Dası́d aHemorheology and Haemostasis Unit, Service of Clinical Pathology, La Fe University Hospital, Valencia, Spain bResearch Universitary Institute “Dr. Viña Giner”, Molecular and Mitochondrial Medicine, Catholic University of Valencia, “San Vicente Mártir”, Valencia, Spain cFaculty of Medicine, Catholic University of Valencia “...
متن کاملDefining the phenotypes of sickle cell disease.
The sickle cell gene is pleiotropic in nature. Although it is a single gene mutation, it has multiple phenotypic expressions that constitute the complications of sickle cell disease. The frequency and severity of these complications vary considerably both latitudinally in patients and longitudinally in the same patient over time. Thus, complications that occur in childhood may disappear, persis...
متن کاملSteady state hemoglobin concentration and packed cell volume in homozygous sickle cell disease patients in Lagos, Nigeria
Background: Sickle cell disease is a genetic disorder of hemoglobin causing myriad of pathology including anemia. The purpose of this study was to evaluate the baseline values of steady state hemoglobin and packed cell volume as a guide to managing the early recognition of hemolytic crises in sickle cell anemia. Methods: A cross-sectional study was conducted among the sickle cell patients atte...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2004
ISSN: 0007-1048
DOI: 10.1111/j.1365-2141.2004.05025.x